Evidence map›Paper›PMID 41256112›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological disease.

Winston H Dredge, Kailash Bp, Aline Réal, Benjamin Z Muller, Beomjin Jang, Ting Fu, Hyomin Seo, Hong-Hee Won, Michael S Breen, Xinshu Xiao and 3 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Winston H DredgeRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7897-3185
Kailash BpRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1501-4881
Aline RéalNew York Genome Center, New York, NY, USA.ORCID 0000-0002-9437-4411
Benjamin Z MullerRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0004-9712-6378
Beomjin JangRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0008-9056-1480
Ting FuDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0936-732X
Hyomin SeoRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0003-3457-5945
Hong-Hee WonDepartment of Digital Health, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea.ORCID 0000-0001-5719-0552
Michael S BreenDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6739-939X
Xinshu XiaoDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9362-8029
David A KnowlesNew York Genome Center, New York, NY, USA.ORCID 0000-0002-7408-146X
Jack HumphreyRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6274-6620
Towfique RajRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9355-5704

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI John Fonda Crary · 2020 to 2026
$31.0M
Human Biomarkers CoreU54NS123743 · NINDS · STANFORD UNIVERSITY · PI PETRUCELLI, LEONARD · 2021 to 2025
$8.2M
Learning the Regulatory Code of Alzheimer's Disease GenomesU01AG068880 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KNOWLES, DAVID ARTHUR, RAJ, TOWFIQUE · 2020 to 2024
$5.8M
The role of peripheral myeloid cells in Alzheimers diseaseR01AG054005 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RAJ, TOWFIQUE · 2017 to 2021
$4.1M
The Role of Myeloid Cells in Parkinson's DiseaseR01NS116006 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Towfique Raj · 2021 to 2026
$4.0M
Regulation and function of dsRNAs derived from retrotransposable elements in ADR01AG078950 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xinshu Grace Xiao · 2022 to 2026
$3.2M
Systematic approaches to deciphering regulation and function of RNA editing in brainR01MH123177 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI XIAO, XINSHU GRACE · 2021 to 2025
$3.1M
Modeling the impact of regulatory and splicing variants on cellular function in Alzheimer's diseaseRF1AG065926 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRENNAND, KRISTEN JENNIFER, RAJ, TOWFIQUE · 2021 to 2021
$2.4M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
The impact of Alzheimer's disease susceptibility alleles on microglia transcriptomeR21AG063130 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DE WITTE, LOTJE DOROTHEE, RAJ, TOWFIQUE · 2020 to 2020
$599k
NCATS NIH HHS UL1 TR004419NIA NIH HHS F31 AG084223NIA NIH HHS P30 AG066514NIA NIH HHS R01 AG054005NIA NIH HHS R01 AG078950NIA NIH HHS R21 AG063130NIA NIH HHS R21 AG091272NIA NIH HHS R56 AG088669NIA NIH HHS RF1 AG065926NIA NIH HHS U01 AG068880NIH HHS S10 OD026880NIH HHS S10 OD030463NIMH NIH HHS R01 MH123177NINDS NIH HHS R01 NS116006NINDS NIH HHS U54 NS123743
6 · The paper itself

Abstract

Adenosine-to-inosine (A-to-I) RNA editing is among the most abundant post-transcriptional modifications, whose role in homeostasis and disease of the central nervous system (CNS) has been extensively reported. Regulation of A-to-I editing by

Identifiers

PMID41256112
PMCPMC12622134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.