ArticleChina CDC weekly2025
Epidemiological and Genetic Characterization of Three H9N2 Viruses Causing Human Infections - Changsha City, Hunan Province, China, April 2025.
Article in China CDC weekly, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Genetic and Pathogenicity Studies of Avian Influenza (H9N2) Virus Isolated from Chickens in Jiangsu Province, China, in 2025.Microorganisms · 2026Article
- Cross-reactive human antibody responses to H9N2 influenza virus, New York, United States, 2025.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Molecular epidemiological characteristics of H9N2 subtype avian influenza virus in the external environment of western Zhejiang, China, 2014-2025.Frontiers in public health · 2026Article
- Advances and prospects of mucosal vaccination in the prevention and control of avian influenza.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What is already known about this topic?: A total of 117 H9N2 cases of human infection of Chinese origin had been reported to the World Health Organization (WHO) by May 9, 2025, with 22 of them originating in Hunan Province. What is added by this report?: This article reported on the investigation of three new H9N2 avian influenza virus (AIV) infections detected in Changsha, Hunan Province, in April 2025. No epidemiological link was found among them. Exposure to live poultry was identified as the primary risk factor for infection. Sequence analysis of the three H9N2 AIVs showed a similarity of 99.71%-99.82% between hemagglutinin (HA), and the homology of the neuraminidase (NA) genes was 98.41%-99.83%. Although the tests showed that the HA had enhanced binding ability to upper respiratory tract cells' receptors, no evidence of sustained human-to-human transmission has been found so far. What are the implications for public health practice?: This study indicated that H9N2 AIV remains a public health issue in China. We need to strengthen publicity and education efforts to inform people of the potential risk of avian influenza virus, especially to keep children away from poultry and poultry-related facilities, to effectively prevent the occurrence of avian influenza A(H9N2) infection.
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