ArticleJournal of clinical practice and research2024
Value of Diverse Hematological Markers in Fibromyalgia: A Real-World Study.
Article in Journal of clinical practice and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the systemic immune-inflammation index (SII) in rheumatic diseases.Frontiers in immunology · 2026Pooled it
- The Neutrophil-to-Lymphocyte Ratio in Fibromyalgia: A Systematic Review with a Neuroimmune Perspective.Brain sciences · 2026Review
- The Role of Immature Granulocytes in Fibromyalgia: An Indicator of Subclinical Inflammation?Biomedicines · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this study is to assess the diagnostic accuracy and potential role in reflecting systemic inflammation of a broad range of blood cell-derived indexes in fibromyalgia (FM). The efficacy of hematological markers, including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and systemic inflammation aggregate index (AISI) in demonstrating systemic inflammation has not yet been investigated in FM. Materials and Methods: Among the 2,829 patients assessed, a total of 502 patients and 90 age- and sex-matched individuals were involved in the study. Demographic characteristics, C-reactive protein, erythrocyte sedimentation rate, and hematological indexes [platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), SII, SIRI, and AISI] were calculated. Laboratory findings were compared between study groups. Receiver operating characteristic (ROC) analysis was utilized to assess their diagnostic potential. Results: Patients had significantly higher SII, SIRI, and AISI values than controls (p=0.011, p=0.004, and p<0.001, respectively). No significant differences existed in NLR, MLR, and PLR between groups. According to the ROC analysis, SII, SIRI, and AISI exhibited statistically significant accuracy in differentiating FM from controls (p=0.010, p=0.003, and p=0.002, respectively). However, the area under the curve values (95% confidence interval) of SII, SIRI, and AISI were 0.584 (0.543-0.624), 0.594 (0.553-0.634), and 0.618 (0.569-0.648), respectively. Conclusion: SII, SIRI, and AISI values are higher in FM, reflecting a potentially increased inflammatory status. Yet, their diagnostic performance is below the acceptable level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.