Evidence map›Paper›PMID 41255962›Full record

ArticleFrontiers in molecular neuroscience2025

Focal postnatal deletion of

Carlie McCoy, Mary Dusing, Lilian G Jerow, Grace C Winstel, Felix Zhan, Jason L Rogers, Madison Wesley, J Brian Otten, Steve C Danzer, Candi L LaSarge

Abstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlie McCoyDivision of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Mary DusingDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Lilian G JerowNeuroscience Graduate Program, University of Cincinnati, OH, United States.
Grace C WinstelDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Felix ZhanDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Jason L RogersNoldus Information Technology Inc., Leesburg, VA, United States.
Madison WesleyDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
J Brian OttenDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Steve C DanzerDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Candi L LaSargeDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Funding

Selective disruption of hippocampal dentate granule cells in autism: impact of PTR01NS065020 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2023
$6.1M
mTOR regulation of aberrant neuronal integration and epileptogenesis in epilepsyR01NS062806 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2019
$3.6M
Anti-epileptogenic role of mTOR activation among hippocampal interneuronsR01NS121042 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2022 to 2025
$2.0M
Mechanisms of focal epileptogenesis in mTORopathiesR35NS143046 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Steve C Danzer · 2025 to 2026
$1.6M
NINDS NIH HHS R01 NS062806NINDS NIH HHS R01 NS065020NINDS NIH HHS R01 NS121042NINDS NIH HHS R35 NS143046
6 · The paper itself

Abstract

Introduction: Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either the Methods: Results: All adult fTSC2 KO mice implanted with cortical electrodes had seizures, whereas no control mice did. Histological analyses showed that virally infected cells in fTSC2 KO mice had enlarged somas and increased mTOR activation (pS6 expression). These fTSC2 KO mice also had decreased parvalbumin and somatostatin interneuron densities in the surrounding cortex. fTSC2 KO mice displayed increased anxiety-like behaviors, spending significantly less time in the center of the novel environment compared to controls. Conclusion: A focal, postnatal deletion of

Indexed as

cortical developmentepileptogenesismTORparvalbuminsomatostatintuberous sclerosis complex

Identifiers

PMID41255962
PMCPMC12620446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.