ArticleJournal of clinical practice and research2024
The Systemic Administration of Na
Article in Journal of clinical practice and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Citronellal Alleviates Cognitive Impairment by Inhibiting NHE1-Mediated Mitochondrial Damage in Vascular Dementia.Applied biochemistry and biotechnology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Disruptions in pH regulation are known to cause impairments in cognitive processes such as learning and memory, leading to various neurological disorders. Na Materials and Methods: A total of 20 male Wistar rats weighing between 240 g and 360 g were divided randomly into two groups: control (n=10) and cariporide (n=10). The cariporide group received a dosage of 10 mg/kg of cariporide added to the drinking water of the rats for three weeks. The Morris Water Maze (MWM) test was conducted on all groups. Distance moved (DM), escape latency (EL), swimming speed (SS), mean distance to the platform (MdtP), and time spent in the target quadrant (TSTQ) of the rats were recorded using the monitoring and recording system. Results: The DM to find the platform and EL time did not show significant differences between the groups (p>0.05). The SS of the rats in the cariporide group significantly decreased compared to the control group on all days (p<0.05). The MdtP was statistically significantly increased in the cariporide group on the 2 Conclusion: The findings of this study indicate that systemic inhibition of NHE1 with cariporide affects hippocampal plasticity, leading to impairments in learning and memory. To elucidate its role in neurodegenerative diseases, further research should investigate cariporide's effect on hippocampal synaptic plasticity.
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Registered trials
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