ReviewJournal of clinical practice and research2023
Impact of Polyphenolic Compounds on the MAPK Signaling Pathway against Carcinogenesis.
Review in Journal of clinical practice and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Polyphenol-based modulation of the Glo1-Nrf2-RAGE axis in diabetes and neurodegeneration: mechanistic evidence, translational constraints, and critical appraisal.Frontiers in pharmacology · 2026Review
- From colon wall to tumor niche: Unraveling the microbiome's role in colorectal cancer progression.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitogen-activated protein kinase (MAPK) signaling pathway is one of the signaling pathways involved in cellular life. Dysregulation of the MAPK signaling pathway is implicated in the emergence of diverse stages of carcinogenesis, including metastasis, angiogenesis, apoptosis, invasion, proliferation and cell differentiation. Therefore, it contributes significantly to the process of carcinogenesis. The mitogen-activated protein kinase signaling pathway presents numerous molecular components that can be regulated against carcinogenesis. Many studies have shown that polyphenols in various dietary sources have important contributions to the regulation of this pathway. This contribution occurs by inducing cell death, altering immunity, blocking angiogenesis and suppressing cancerous cell growth. Numerous studies have been conducted on this aspect of polyphenolic compounds, with encouraging outcomes. Its clinical efficacy against cancer is also being investigated. This study focuses on the importance of mitogen-activated protein kinase signaling pathway in carcinogenesis by emphasizing the properties of polyphenolic compounds. The study aims to research the clinical effectiveness of polyphenolic compounds in regulating the MAPK signaling pathway against cancer.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.