ArticleJournal of clinical practice and research2025
The Effect of Retinoic Acid and Bevacizumab on Ovarian Hyperstimulation Syndrome.
Article in Journal of clinical practice and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Effect of Bazedoxifene and Fulvestrant for Preventing Ovarian Hyperstimulation Syndrome: An Experimental Study.Journal of clinical medicine · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Ovarian hyperstimulation syndrome (OHSS) is an undesired outcome of controlled ovarian stimulation, commonly used in infertility treatment during Materials and Methods: A hyperstimulation model was created using 40 Wistar albino rats, each 22 days old. The rats were divided into four groups. Group 1 was the negative control group, Group 2 was the positive control group, Group 3 was the bevacizumab-administered group after ovarian hyperstimulation, and Group 4 was the retinoic acid-administered group after ovarian hyperstimulation. Serum estradiol and vascular endothelial growth factor (VEGF) levels were evaluated. Peritoneal fluid was collected using a syringe, and the presence of peritoneal fluid was recorded observationally. Hematoxylin and eosin staining and Masson's trichrome staining were performed on the ovaries. Immunohistochemical staining for VEGF and estrogen receptors was conducted. Results: Retinoic acid treatment significantly reduced peritoneal fluid and inhibited fluid leakage, whereas bevacizumab treatment resulted in a slight reduction of peritoneal fluid. The number of tertiary and secondary follicles remained unaffected by both bevacizumab and retinoic acid treatment. However, the number of primary follicles significantly decreased in the bevacizumab and retinoic acid treatment groups. Retinoic acid treatment significantly reduced estrogen receptor (ER) in the stromal compartment. Conclusion: Both retinoic acid and bevacizumab appear to be effective in treating OHSS. Additionally, retinoic acid and bevacizumab influence the initial stages of follicular development. Future studies are essential to determine the optimal dosage and timing for these therapeutic agents.
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