ArticlePlastic and reconstructive surgery. Global open2025
Dual-plane Product Technique for Earlobe Rejuvenation: Apriline Hyaluronic Acid Filler and Apriline Skin Booster Injection.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Chitosan-based hydrogel, along with citrus-derived extracellular vesicles and clove extract: advanced skin wound dressing.Bioprocess and biosystems engineering · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Age-related earlobe changes such as volume loss, wrinkling, and reduced projection can subtly affect facial balance. Hyaluronic acid (HA) fillers restore volume, whereas low-viscosity HA "skin boosters" improve hydration and texture. Combining these products may enhance rejuvenation outcomes. The objective of this study was to evaluate the safety and short-term outcomes of a dual-product HA injection protocol targeting both volume and skin quality in moderately aged earlobes. Methods: In this prospective case series, 30 women (aged 40-65 y) received a standardized, 3-step treatment: (1) deep volumization with cross-linked HA via 22G cannula, (2) superficial skin booster using 30G needle, and (3) optional refinement with high G' HA via 27G needle. Assessments at baseline, 1 month, and 3 months included skin hydration (Corneometer), patient satisfaction (5-point Likert), procedural pain (visual analog scale), and adverse events. Results: Hydration improved significantly (45.2% at baseline to 54.5% at 3 mo; Conclusions: Layered HA injections targeting both structural and superficial compartments seem to be safe, well tolerated, and associated with meaningful aesthetic improvements. Further studies are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.