Evidence map›Paper›PMID 41255709›Full record

ArticleNAR molecular medicine2025

Delineation of signaling routes that underlie differences in macrophage phenotypic states.

Tiberiu Totu, Jonas Bossart, Elana Caire, Katharina Sribike, Chen Li, Markus Rottmar, Bettina Sobottka, Guocan Yu, Vanesa Ayala-Nunez, Marija Buljan

Abstract read
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Article in NAR molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tiberiu TotuDepartment Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), 9014 St. Gallen, Switzerland.ORCID https://orcid.org/0000-0001-8268-1740
Jonas BossartDepartment Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), 9014 St. Gallen, Switzerland.
Elana CaireDepartment Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), 9014 St. Gallen, Switzerland.
Katharina SribikeDepartment Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), 9014 St. Gallen, Switzerland.
Chen LiMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, 3800 Victoria, Australia.ORCID https://orcid.org/0000-0002-1847-754X
Markus RottmarDepartment Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), 9014 St. Gallen, Switzerland.
Bettina SobottkaDepartment of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
Guocan YuDepartment of Chemistry, Tsinghua University, 100190 Beijing, China.
Vanesa Ayala-NunezDepartment Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), 9014 St. Gallen, Switzerland.
Marija BuljanDepartment Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), 9014 St. Gallen, Switzerland.ORCID https://orcid.org/0000-0003-3615-6691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages represent a major immune cell type in tumor microenvironments, they exist in multiple functional states and are of strong interest for therapeutic reprogramming. While signaling cascades defining proinflammatory macrophages are better characterized, pathways that drive polarization in immunosuppressive macrophages are incompletely mapped. Here, we performed an in-depth characterization of signaling events in primary human macrophages in different functional states using mass spectrometry-based (phospho-)proteomic profiling. Analysis of direct and indirect evidence of kinase activities suggested PAK2 and PKCα kinases as important regulators of

Identifiers

PMID41255709
PMCPMC12430007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.