Evidence map›Paper›PMID 41255668›Full record

ArticleWorld journal of clinical pediatrics2025

Diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis: A prospective case-control study.

Hosam-Eldin M Basiouny, Soha S Allam, Alif A Allam, Shimaa Abdelsattar, Mostafa M Sira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hosam-Eldin M BasiounyDepartment of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom 32511, Menoufia, Egypt.
Soha S AllamDepartment of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom 32511, Menoufia, Egypt.
Alif A AllamDepartment of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom 32511, Menoufia, Egypt.
Shimaa AbdelsattarDepartment of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia 32511, Egypt.
Mostafa M SiraDepartment of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Shebin El-Koom 32511, Menoufia, Egypt. msira@liver.menofia.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal sepsis is a serious health problem, with high morbidity and mortality during the first 28 days of life. Clinical diagnosis at presentation is challenging due to the nonspecific signs and symptoms. Although blood culture is the gold standard for diagnosis, it is not always positive.

aimTo evaluate the diagnostic and prognostic utility of D-dimer and heparin-binding protein (HBP) in neonatal sepsis.

methodsThis prospective case-control study included 90 neonates in two groups: A sepsis group (

resultsLevels of CRP, D-dimer and HBP were significantly higher in the sepsis group compared to the controls. At a cutoff value above 517.9 ng/mL, D-dimer outperformed CRP and HBP in distinguishing sepsis group from controls with 95.6% sensitivity and 97.8% specificity. D-dimer was also a better prognostic marker than the neonatal sequential organ failure assessment (nSOFA) for predicting mortality, with 100% sensitivity and 92.5% specificity

conclusionD-dimer demonstrated superior diagnostic accuracy compared to CRP and HBP in predicting sepsis, and demonstrated superior prognostic accuracy compared to nSOFA in predicting the outcome of neonatal sepsis.

Indexed as

C-reactive proteinD-dimerHeparin-binding proteinMortalityNeonatal sepsis

Identifiers

PMID41255668
PMCPMC12620844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.