ArticleWorld journal of clinical pediatrics2025
Features of patients with uveitis associated with juvenile idiopathic arthritis required eye surgery.
Article in World journal of clinical pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUveitis associated with juvenile idiopathic arthritis (U-JIA) is a vision-threatening condition. Estimates of prevalence of uveitis in patients with known juvenile idiopathic arthritis range from 11.6% to 30.0%. First-line treatment includes topical glucocorticoids; methotrexate (MTX) is used if topical corticosteroids are ineffective. In severe cases biological therapy like adalimumab may be prescribed. Complications, including vision loss, may be related to the disease and the ongoing treatment (topical corticosteroids). In severe cases surgical intervention is often necessary and is typically associated with poor vision outcomes.
aimTo highlight the characteristics of operated U-JIA and to identify predictors of treatment failure.
methodsA retrospective cohort study analyzed data from 68 pediatric patients (under 18 years old) with U-JIA between 2007 and 2023. The study focused on demographic, clinical, treatment, and outcome variables. Survival analysis using Kaplan-Meier curves and the Cox proportional hazards model was performed to estimate the impact of surgical intervention on the course of uveitis and to identify predictors of treatment failure.
resultsEye surgery was performed on 17 (25%) patients with U-JIA. It was associated with an earlier onset of uveitis (
conclusionOperated patients exhibited an aggressive early-onset uveitis profile that needed early and more intensive treatment. Delayed and failed MTX treatment as well as delayed switching to biologics often required subsequent eye surgery.
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