ArticleJournal of clinical practice and research2025
Hepatitis B Serological Tests and Vitamin D Values: A Seasonal Assessment.
Article in Journal of clinical practice and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Evaluation of soluble transferrin receptor and malondialdehyde levels associated with ferroptosis in children with familial Mediterranean fever in remission.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Assessment of Nutritional Status in Children with Familial Mediterranean Fever Using Prognostic Nutritional Index and Controlling Nutritional Status Score: Relationship with Clinical Findings and MEFV Mutations.Children (Basel, Switzerland) · 2025Article
- Evaluation of Sleep Disturbances and Depression in Children with Juvenile Idiopathic Arthritis Using the Beck Depression Inventory and Child Sleep Disorder Scale: Relationship with Leukocyte and Neutrophil Counts.Children (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Hepatitis B virus (HBV), a significant global health concern, remains a source of infection despite the availability of effective vaccines. The progression of the disease is influenced by HBV antigens and autoimmune reactions. A deficiency in the immunomodulatory vitamin D is associated with the severity of various illnesses. The purpose of this research was to explore the relationship between HBV serological test results and 25-hydroxyvitamin D levels. Materials and Methods: The study included 120,004 HBV serological tests (Hepatitis B surface antigen (HBsAg), Hepatitis B e-antigen (HBeAg), anti-HBsAg, anti-HBeAg, antibodies to Hepatitis B core immunoglobulin G (anti-HBc IgG), and anti-HBc IgM) and 62.835 25-hydroxyvitamin D tests. Results: In spring, summer, and fall, 25-hydroxyvitamin D levels in HBsAg-positive individuals were lower compared to HBsAg-negative individuals. Conversely, 25-hydroxyvitamin D levels in individuals positive for anti-HBsAg were higher than those in anti-HBsAg-negative individuals across all seasons. Furthermore, in both cases of 25-hydroxyvitamin D deficiency and optimal 25-hydroxyvitamin D levels, individuals positive for anti-HBsAg showed higher 25-hydroxyvitamin D values than those negative for anti-HBsAg. Additionally, individuals positive for anti-HBc IgG demonstrated higher 25-hydroxyvitamin D levels compared to anti-HBc IgG-negative individuals during winter and fall. Moreover, 25-hydroxyvitamin D levels in individuals negative for anti-HbeAg were found to be below the optimal range. Conclusion: In conclusion, there may be a relationship between 25-hydroxyvitamin D levels and hepatitis B serological test positivity. Therefore, vitamin D levels should be monitored in populations affected by HBV.
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