ArticleJournal of clinical practice and research2024
Investigation of the Effects of SOD1 +35A/C and GPx-3 +1494A/G Gene Polymorphisms in Patients With Acne Vulgaris.
Article in Journal of clinical practice and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Objective: Acne vulgaris (AV) is a common skin disorder. Genotypic variations of antioxidant-related genes may directly influence the function of AV-related genes by mitigating the risk of oxidative stress. This study aimed to investigate the impact of SOD1 +35A/C and GPx-3 +1494A/G gene polymorphisms in patients with AV. Materials and Methods: The study comprised 81 healthy controls and 81 AV patients. The GPx-3 +1494A/G genotype was evaluated using Allele-Specific Polymerase Chain Reaction (AS-PCR), while the SOD1 +35A/C genotype was analyzed through the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique. Results: Genotype and allele frequencies of the SOD1 +35A/C gene polymorphism differed significantly between the AV patients and the control group (χ Conclusion: The findings of this study indicate a correlation between the SOD1 +35A/C polymorphism and an increased incidence of AV.
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