ReviewFrontiers in medicine2025
The role of reactive oxygen species-mitophagy regulation in the treatment of osteoarthritis by active Chinese herbal medicine monomers: a review.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Traditional Chinese medicine-derived monomers protect chondrocytes and delay osteoarthritis progression by regulating mitochondrial quality control.Frontiers in molecular biosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary pathological features of osteoarthritis (OA) involve articular cartilage degradation and structural damage, coupled with osteophyte formation and inflammatory responses. As aging populations expand, the prevalence of knee osteoarthritis has risen substantially, severely compromising patients' quality of life. Current therapeutic strategies for knee osteoarthritis remain limited in clinical efficacy, creating an urgent need for novel treatments that are both effective and safe. Chinese herbal medicine monomers have demonstrated significant potential in OA management, offering multi-pathway therapeutic effects, multi-target modulation, and favorable safety profiles. However, its underlying mechanisms require further elucidation. Mitophagy, a selective mitochondrial quality control mechanism that eliminates reactive oxygen species-damaged organelles, plays a crucial role in maintaining chondrocyte homeostasis and function. Emerging evidence highlights the regulatory significance of mitophagy in OA progression, presenting novel therapeutic perspectives. This review comprehensively analyzes the molecular mechanisms and physiological roles of the oxidative stress-mitophagy axis in knee osteoarthritis pathogenesis, while summarizing recent advances in herbal monomer-mediated regulation of this pathway. Future research directions are proposed to facilitate the systematic exploration and clinical translation of Chinese herbal medicine in OA therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.