ArticleJuntendo medical journal2025
Molecular Mechanisms of Heatstroke: Pathophysiology and Cell Death Pathways.
Article in Juntendo medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Occupational heatstroke-induced acute kidney injury: a narrative review of mechanisms, biomarkers, and the timing of blood purification initiation.Renal failure · 2026Review
- Histopathological and molecular mechanisms of multi-organ damage in heat stroke: Endothelial failure, immune crosstalk, and regulated cell death pathways.Histology and histopathology · 2026Review
- Mechanisms and Intervention Strategies for Heat Stroke-Associated Myocardial Dysfunction: A Narrative Review.The western journal of emergency medicine · 2026Review
- Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Heat stress-induced mitochondrial damage and its impact on leukocyte function.Journal of intensive care · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heatstroke is a severe, life-threatening condition characterized by a core body temperature exceeding 40°C, accompanied by central nervous system dysfunction such as confusion, seizures, or coma. It often presents with systemic inflammation and multi-organ failure, including injury to the liver, kidneys, brain, and coagulation system. The molecular pathogenesis of heatstroke is multifactorial, involving a cascade of intracellular and extracellular events triggered by excessive heat. These include protein denaturation, loss of cellular homeostasis, oxidative stress, mitochondrial dysfunction, and the release of damage-associated molecular patterns (DAMPs) that activate immune responses. In parallel, regulated cell death pathways such as apoptosis, necroptosis, pyroptosis, and ferroptosis are initiated, amplifying tissue injury. Key molecular mediators include heat shock proteins, proinflammatory cytokines, and reactive oxygen species. This review summarizes current understanding of the molecular and cellular mechanisms underlying heatstroke, highlighting potential biomarkers and therapeutic targets that may improve diagnosis, prognostication, and clinical management of this increasingly relevant condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.