Evidence map›Paper›PMID 41255551›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)

Risk factor profiles and cognitive function in older adults: the Brain Health Support Program Study.

Caroline S Duchaine, Manuel Montero-Odasso, Haakon B Nygaard, Paul W H Brewster, Diane M Jacobs, Nicole D Anderson, Penelope J Slack, January M Durant, Jody-Lynn Lupo, Howard Chertkow and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caroline S DuchaineCentre de recherche de l'Institut universitaire de gériatrie de Montréal (CRIUGM) Montréal Québec Canada.ORCID https://orcid.org/0000-0002-3716-1911
Manuel Montero-OdassoGait and Brain Laboratory, Lawson Health Research Institute, Parkwood Institute London Ontario Canada.
Haakon B NygaardDepartment of Medicine, Division of Neurology University of British Colombia Vancouver British Colombia Canada.
Paul W H BrewsterInstitute on Aging & Lifelong Health University of Victoria Victoria British Columbia Canada.
Diane M JacobsAlzheimer's Disease Cooperative Study, Department of Neurosciences University of California San Diego La Jolla California USA.
Nicole D AndersonRotman Research Institute Baycrest Academy for Research and Education North York Ontario Canada.
Penelope J SlackDepartment of Medicine, Division of Neurology University of British Colombia Vancouver British Colombia Canada.
January M DurantAlzheimer's Disease Cooperative Study, Department of Neurosciences University of California San Diego La Jolla California USA.
Jody-Lynn LupoAlzheimer's Disease Cooperative Study, Department of Neurosciences University of California San Diego La Jolla California USA.
Howard ChertkowRotman Research Institute Baycrest Academy for Research and Education North York Ontario Canada.
Howard H FeldmanAlzheimer's Disease Cooperative Study, Department of Neurosciences University of California San Diego La Jolla California USA.
Sylvie BellevilleCentre de recherche de l'Institut universitaire de gériatrie de Montréal (CRIUGM) Montréal Québec Canada.
Canadian Consortium on Neurodegeneration in Aging (CCNA), CAN‐THUMBS UP Study Group

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
NIA NIH HHS P30 AG062429
6 · The paper itself

Abstract

backgroundDementia risk factors coexist and interact in meaningful ways. Identifying risk profiles can inform prevention strategies.

methodsThis study examined profiles using seven modifiable risk factors and their associations with cognition and sex among older adults at risk of dementia. Risk profiles were identified using principal component analysis, and linear regressions assessed their associations with cognition.

resultsThree profiles emerged: (1) better sleep and social/psychological health; (2) better diet, physical activity, and vascular health; and (3) better cognitive engagement. Similar profiles were observed in women, except that better cognitive engagement grouped with poorer vascular health. In men, better cognitive engagement grouped with better vascular health and vision/hearing, while lower cognitive engagement was grouped with better sleep and social/psychological health. The lower cognitive engagement profile in men was associated with poorer cognition. DISCUSSION: Prevention strategies should target meaningful combinations of risk factors to improve dementia prevention. Further research is needed to validate and refine these profiles. Highlights: This study evaluated risk profiles using a broad range of modifiable risk factors.This is the first study to analyze such profiles in a Canadian population, stratified by sex.Risk profiles differed by sex, especially for the cognitive engagement risk factor.In men, lower cognitive engagement profile was associated with poorer cognition.

Indexed as

Alzheimer's diseasecognitiondementialifestyle risk factorsmodifiable risk factorsprincipal component analysisrisk profiles

Identifiers

PMID41255551
PMCPMC12623131

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.