ArticleFrontiers in endocrinology2025
Real-world insights from acute management of potassium disorders in diabetic ketoacidosis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Indicators for predicting continuous insulin infusion therapy-related hypokalemia: multicenter retrospective cohort study.Endocrine journal · 2026Article
- Potassium Homeostasis and the Systemic Consequences of Intracellular Potassium Deficiency: From Molecular Mechanisms to Clinical Manifestations.Biomolecules · 2026Review
- Acute kidney injury and length of ICU stay in diabetic ketoacidosis: a retrospective cohort study.Frontiers in endocrinology · 2026Article
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10 authors.
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Abstract
Background: Diabetic ketoacidosis (DKA) is a severe hyperglycemic emergency characterized by metabolic acidosis and electrolyte disturbances. The optimal strategy for potassium replenishment in DKA remains incomplete. This study comprehensively characterized potassium disturbances in DKA and evaluated the effectiveness of potassium replenishment strategies, with a focus on the risk of hypokalemia during treatment. Methods: In this multicentre retrospective cohort study, we enrolled the consecutive DKA patients admitted to seven tertiary centres across eastern, central and western China (1 January 2021-31 December 2023). Demographics, biochemical parameters and daily potassium chloride (KCl) replenishment were extracted and evaluated. We used multivariable logistic regression to identify predictors of hypokalaemia during treatment, internally validated the model, and constructed a practical nomogram. Results: A total of 571 eligible subjects were included in the analysis. On admission, blood glucose, arterial pH, HCO Conclusions: Potassium imbalances were highly prevalent in DKA. Although hyperkalemia was more common on admission, hypokalemia frequently developed during treatment. Daily 6.0 g KCl replenishment was superior to lower doses in predicting hypokalaemia. This study provided the full spectrum of potassium disorders in DKA and delivered an evidence-based, patient-specific replenishment framework.
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