Evidence map›Paper›PMID 41255399›Full record

ReviewJournal of clinical and experimental dentistry2025

Cryosurgery in oral lesions.

Eleni Georgakopoulou, Panagiota Loumou, Dimitrios Sgouros, Akhilanand Chaurasia, Antonios Panagiotopoulos

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07708389 (Comparison of Salivary Cortisol Response and Early Postoperative Outcomes Following 970-nm Diode Laser and Liquid Nitrogen Cryotherapy in Maxillary Labial Frenectomy), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07708389 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of Salivary Cortisol Response and Early Postoperative Outcomes Following 970-nm Diode Laser and Liquid Nitrogen Cryotherapy in Maxillary Labial Frenectomy: A Randomized Single-Blind Clinical Trial

TypeinterventionalSponsorKutahya Health Sciences UniversityRan2026 to 2027Enrolled40ConditionsMaxillary Labial Frenulum Abnormality, Hypertrophic Maxillary Labial FrenulumArms970-nm Diode Laser Frenectomy, Liquid Nitrogen Cryotherapy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eleni GeorgakopoulouMD, DDS, MSc, PhD. Private Practice, 4 Fokaias St, Athens 14232, Greece.
Panagiota LoumouMD, DDS, PhD. Private Practice, 44 Nefelis St, Athens, Greece.
Dimitrios SgourosMD, PhD. 2nd Department of Dermatology and Venereology, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari 12462, Athens, Greece.
Akhilanand ChaurasiaMDS, Department of Oral Medicine and Radiology, King George's Medical University, India.
Antonios PanagiotopoulosMD. Former Head of the Cryosurgery Department, Hospital "A. Syggros," Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryosurgery is a treatment method that employs extremely low temperatures to address various diseases. Since the early 1960s, liquid nitrogen has been utilized in dermatology, oral surgery, ophthalmology, gynecology, urology, cardiology, and internal organ surgery. It is the preferred treatment for numerous skin conditions due to its versatility in addressing benign, precancerous, and malignant diseases. The application of cryosurgery as a therapeutic approach for oral mucosal diseases has been shaped by the treatment of analogous dermatological conditions. Considering the potential of cryosurgery applications, it has been utilized as an alternative therapy for various oral lesions.

Identifiers

PMID41255399
PMCPMC12621005

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.