ReviewJournal of clinical and experimental dentistry2025
Pre-post intervention changes in salivary biomarkers after dental treatment in children with caries: A systematic review and meta-analysis.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
Background: Dental caries is a prevalent chronic disease in children that induces local inflammation and oxidative stress. Salivary biomarkers offer a non-invasive tool for monitoring biological changes associated with dental interventions. This study aims to evaluate pre- and post-treatment changes in salivary biomarkers of inflammation and oxidative stress in children with caries and to synthesize evidence on the biological response to treatment. Material and Methods: This systematic review and meta-analysis followed PRISMA 2020 guidelines and was prospectively registered in PROSPERO. A comprehensive literature search identified longitudinal and pre-post studies assessing salivary biomarkers in pediatric caries patients treated with restorative or preventive interventions. Risk of bias was assessed using ROBINS-I, and evidence quality with GRADE. Meta-analysis was conducted using a random-effects model. Results: Six studies involving 202 children (aged 3-12) were included. The pooled standardized mean difference (SMD) was 0.51 (95% CI: 0.37-0.65), favoring a post-treatment improvement in biomarker levels. Heterogeneity was moderate (I² = 45.6%; τ² = 0.012). ROBINS-I indicated moderate risk of bias; GRADE rated overall certainty of evidence as moderate. Conclusions: Therapeutic dental interventions in children with caries are associated with measurable improvements in salivary biomarkers, suggesting reduced inflammation and oxidative stress following treatment.
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Registered trials
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