Evidence map›Paper›PMID 41255390›Full record

ArticleNAR molecular medicine2025

Indole-containing inhibitors with improved efficacy targeting the gyrase of

Shankar Bhattarai, Vinay Shankar Tiwari, Benjamin Tam, Aviv Rozen, Adam Soffer, Samuel Durbah, Sarah Adi Eisdorfer, Angeliki Giannoulis, Daniella Goldfarb, Barak Akabayov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shankar BhattaraiDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.ORCID https://orcid.org/0000-0001-7699-3086
Vinay Shankar TiwariDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.
Benjamin TamDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.
Aviv RozenDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.
Adam SofferDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.
Samuel DurbahDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.
Sarah Adi EisdorferDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.
Angeliki GiannoulisDepartment of Chemical and Biological Physics, Weizmann Institute of Science, 234 Herzl St. Rehovot 7610001, Israel.
Daniella GoldfarbDepartment of Chemical and Biological Physics, Weizmann Institute of Science, 234 Herzl St. Rehovot 7610001, Israel.
Barak AkabayovDepartment of Chemistry, Ben-Gurion University of the Negev, David Ben-Gurion Blvd. 1, Beer-Sheva 8410501 P.O Box 653, Israel.ORCID https://orcid.org/0000-0002-3882-2742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis is a major cause of mortality worldwide, with drug-resistant strains complicating its treatment. We report the discovery of small-molecule inhibitors targeting the gyrase of

Identifiers

PMID41255390
PMCPMC12429953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.