ArticleHealth science reports2025
Human Papillomavirus Viral Load as Triage Biomarker for High-Grade Cervical Lesions and Invasive Cervical Carcinoma: A Cross-Sectional Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Epidemiology of Human Papillomavirus in the Middle East and North Africa: A Review of Genotypic Prevalence, Vaccination Challenges, and Non-Cervical Clinical Outcomes.Diseases (Basel, Switzerland) · 2026Review
- Human Papillomavirus Viral Load as Triage Biomarker for High-Grade Cervical Lesions and Invasive Cervical Carcinoma: A Cross-Sectional Study.Health science reports · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: We herein evaluated whether intra-tissue HPV viral load may constitute a triage biomarker to differentiate between high-grade precancerous cervical lesions from intra cervical cancer (ICC). Methods: 50 biopsy samples prospectively obtained from women living in Mauritania suffering from high-grade cervical intraepithelial neoplasia (CIN2/3), adenocarcinoma (ADC) or squamous cell carcinoma (SCC) were analysed for HPV genotyping and quantitation carried out using Bioperfectus Multiplex Real Time Human Papillomavirus Genotyping Real Time PCR assay. Results: HPV-positive results were detected in 47 biopsies (12 CIN2/3 and 35 ICC, including 4 ADC and 31 SCC). The cumulative HPV viral loads of any HPV and high risk-HPV (HR-HPV) in ICC were significantly higher than those in CIN2/3 ( Conclusion: Our observations show that cumulative HPV viral load in cervical tissue may constitute a relevant biomarker associated with the severity of HPV-related cervical lesions. HPV viral load in cervical tissue could be used as a triage tool for aggressive ICC in advanced cervical lesions.
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