Evidence map›Paper›PMID 41255351›Full record

ArticleJournal of sleep research2026

Neurometabolic Response to Apneic Stimuli Tracks Global Grey Matter Volume Deficits in Patients With Obstructive Sleep Apnea.

Jeffrey B Dennison, Pei-Hsin Wu, Michael C Langham, Richard J Schwab, John A Detre, Felix W Wehrli

Abstract read
In one paragraph

Article in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeffrey B DennisonDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-0557-3548
Pei-Hsin WuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Michael C LanghamDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Richard J SchwabDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
John A DetreDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-8115-6343
Felix W WehrliDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3430-1840

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Time-Resolved MRI Method for EEG Assisted Concurrent Mapping of Cerebral Oxygen Metabolism and Airway Structure in Obstructive Sleep ApneaR01HL172928 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Felix W Wehrli · 2024 to 2026
$2.0M
Neurometabolic Assessment of Obstructive Sleep Apnea by MRIR01HL122754 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2015 to 2018
$1.7M
NIH HHS P41EB029460NIH HHS R01HL122754NIH HHS R01HL172928
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) has been linked to cortical atrophy and increased risk of neurodegeneration, a process potentially mediated by neurometabolic dysregulation. Recent work using high temporal-resolution metabolic MRI found greater changes in the cerebral metabolic rate of oxygen consumption (CMRO

Indexed as

Gray MatterSleep Apnea, ObstructiveAdultBrainBreath HoldingCerebrovascular CirculationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOxygen ConsumptionPolysomnographycerebral oxygen metabolismgrey matter volume fractionsleep apnea

Identifiers

PMID41255351
PMCPMC13193465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.