Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
James B HayesDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0002-9321-212X
Dharmendra ChoudharyDivision of Genetic Medicine, Department of Medicine (D.C., D.R., E.W.K.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-8657-6005
Dylan RitterDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).
Abigail C Neininger-CastroDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0001-5104-4407
Alaina H WilletDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0002-0163-4772
Leah R CaplanDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0002-6594-1608
Yu WangDepartment of Biostatistics (Y.W., X.L., Q.L.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-2819-4551
Xiao LiuDepartment of Biostatistics (Y.W., X.L., Q.L.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-0654-7333
Nilay TanejaDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0002-9046-0953
Zachary C SanchezDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).
David W J ArmstrongDivision of Cardiovascular Medicine (D.W.J.A.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-3198-7277
Cynthia A Reinhart-KingDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN (K.S., C.A.R.-K., W.D.M.).
Qi LiuDepartment of Biostatistics (Y.W., X.L., Q.L.), Vanderbilt University Medical Center, Nashville, TN.
Matthew J TyskaDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0003-2238-6189
Erdem D TabdanovDepartment of Cell and Biological Systems (E.D.T.), Penn State College of Medicine, The Pennsylvania State University, Hershey.
W David MerrymanDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN (K.S., C.A.R.-K., W.D.M.).ORCID 0000-0001-9662-1503
Quinn S WellsDivision of Cardiovascular Medicine, Department of Medicine (Q.S.W.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-3899-0313
Ela W KnapikDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0002-2977-3619
Dylan T BurnetteDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN (J.B.H., D.R., A.C.N.-C., A.H.W., L.R.C., N.T., Z.C.S., M.J.T., E.W.K., D.T.B.).ORCID 0000-0002-2571-7038
Funding
The assembly and function of cellular contractile systemsR35GM125028 · NIGMS · VANDERBILT UNIVERSITY · PI Dylan Tyler Burnette · 2017 to 2026
$4.2M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
backgroundCardiac sarcomeres generate the fundamental forces of each heartbeat. Cardiac myocytes (CMs) express nonmuscle versions of muscle-specific sarcomere proteins, which have unknown relevance to sarcomere function or heart physiology.
methodsExpression levels of nonmuscle cytoskeletal proteins versus muscle-specific counterparts in CMs were directly compared. Function and subcellular localization of the nonmuscle protein ACTN4 (alpha-actinin-4) in induced pluripotent stem cell-derived CMs were determined using small interfering RNA-mediated knockdown, overexpression, and pharmacological perturbation. Impacts of ACTN4 depletion or knockout on cardiac structure function were evaluated in zebrafish embryos. Left ventricular
results
conclusionsA nonmuscle actinin (ACTN4) populates the cardiac Z-disc. ACTN4 regulates sarcomeric architecture in CMs. ACTN4 influences fractional shortening at the cell level and contractility at the tissue level. Changes in ventricular ACTN4 levels are associated with remodeling and may influence clinical outcomes related to heart failure.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Nonmuscle α-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling. · full record | OpenQuestion