ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Amino Acid Directed Helical Assemblies of Natural Berberine for Chirality-Dependent Photodynamic Antibacterial Therapy.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Self-Assembled Berberine-Sinapic Acid Nanomedicine for Synergistic Chemotherapy.Molecules (Basel, Switzerland) · 2026Article
- Programmable Self-Assembly of Traditional Chinese Medicine (TCM) Monomers: From Molecular Mechanisms to Multifunctional Nanomedicine.International journal of nanomedicine · 2026Review
- Amino Acid Directed Helical Assemblies of Natural Berberine for Chirality-Dependent Photodynamic Antibacterial Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
While the biological effects of chiral pharmaceuticals at molecular level have been extensively studied, research remains limited on how chiral materials derived from natural herbal components exert biomedical effects at higher hierarchical levels. Herein, it is reported that helical nanostructures co-assembled from a traditional Chinese medicine-derived berberine (BBR) and an amino acid derivative (Fmoc-Y) exhibit supramolecular-chirality-dependent photodynamic antibacterial activity. The inherent molecular chirality of the Fmoc-Y component directs the organization of achiral BBR into chiral nanofibers. The experimental results reveal that supramolecular chirality governs nanofiber adsorption on bacterial surfaces and subsequent membrane penetration. Compared with left-handed nanofibers, the chirality-matched right-handed ones enable more efficient intracellular delivery of BBR and reactive oxygen species (ROS) generation, leading to superior bacterial inhibition. This work highlights, for the first time, the unique role of supramolecular chirality in biomedicine applications based on natural herbal components, demonstrating how supramolecular chiral engineering synergizes with natural pharmacophores to develop high-efficiency antimicrobial systems and advanced theranostic platforms.
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