Evidence map›Paper›PMID 41255211›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

NUDT21-mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression.

Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yeping YuDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jixin MaDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Minwei ZhouDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiaodong GuDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yiming ZhouDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhenyang LiDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Tianyu ZhangShanghai Institute of Immunology & Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wei GongLaboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China.
Chuanxin HuangShanghai Institute of Immunology & Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jianbin XiangDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.ORCID https://orcid.org/0000-0001-6150-9052

Funding

National Key R&D Program of China 2021YFA1301403National Natural Science Foundation of China 82172628National Natural Science Foundation of China 82172705National Natural Science Foundation of China 82473043
6 · The paper itself

Abstract

Alternative polyadenylation (APA) is critical for shaping transcriptome diversity by generating mRNA isoforms that differ in the length of their 3'untranslated region (3'UTR). APA dysregulation, a defined feature of tumorigenesis, remains poorly understood in colorectal cancer (CRC). Here, CRISPR/Cas9 screening identifies APA regulator NUDT21 as a key driver of CRC progression. NUDT21 is overexpressed in CRC tumors and correlates with poor prognosis in CRC patients. Genetic ablation of NUDT21 impairs CRC cell proliferation and triggers CD8

Indexed as

CholesterolColorectal NeoplasmsCyclin-Dependent KinasesPolyadenylation3' Untranslated RegionsAnimalsCell Line, TumorCell ProliferationCleavage And Polyadenylation Specificity FactorDisease ProgressionGene Expression Regulation, NeoplasticHumansMice3' Untranslated RegionsCDK19 protein, humanCholesterolCleavage And Polyadenylation Specificity FactorCyclin-Dependent KinasesNudt21 protein, humanalternative polyadenylationCDK19cholesterol biosynthesiscolorectal cancerNUDT21

Identifiers

PMID41255211
PMCPMC12866688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.