Evidence map›Paper›PMID 41255173›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Bioinspired Synthesis of Twin abeo-Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction.

Zoey J Surma, Volodymyr Hiiuk, Eugene Zviagin, Yaxin Ouyang, Alex Chacko, Fengrui Qu, Paul M Zimmerman, Pavel Nagorny

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zoey J Surma *Department of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.
Volodymyr Hiiuk *Department of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.
Eugene Zviagin *Department of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.
Yaxin OuyangDepartment of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.
Alex ChackoDepartment of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.
Fengrui QuDepartment of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.
Paul M ZimmermanDepartment of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.
Pavel NagornyDepartment of Chemistry, University of Michigan, 930 N. University Ave, Ann Arbor, Michigan, 48109, USA.ORCID 0000-0002-7043-984X

Funding

New Methods and Strategies for the Synthesis and Selective Derivatization of Natural ProductsR35GM136341 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pavel Nagorny · 2020 to 2026
$2.6M
NIGMS NIH HHSNIGMS NIH HHS R35 GM136341NIH HHS R35 GM136341
6 · The paper itself

Abstract

This manuscript describes a concise bioinspired synthesis of twin abeo-steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons and a highly oxidized D-ring with an α-pyrone substituent from (+)-methyl estrone. The described synthetic approach features ozonolytic cleavage of the Δ

Indexed as

AldehydesMolecular StructureOxidation-ReductionStereoisomerism3-hydroxybutanalAldehydesEpoxide rearrangementIntramolecular aldolNatural productSinglet oxygenSteroidSynthesis

Identifiers

PMID41255173
PMCPMC12681978

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.