Evidence map›Paper›PMID 41255064›Full record

SynthesisAddiction (Abingdon, England)2026

Social cognition in Korsakoff's syndrome: A meta-analysis.

Kyra Wijnen, Willem S Eikelboom, Yvonne C M Rensen, Gwenny T L Janssen, Roy P C Kessels

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Addiction (Abingdon, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyra WijnenVincent van Gogh Institute for Psychiatry, Centre of Excellence for Korsakoff and Alcohol-related Cognitive Disorders, Venray, the Netherlands.
Willem S EikelboomVincent van Gogh Institute for Psychiatry, Centre of Excellence for Korsakoff and Alcohol-related Cognitive Disorders, Venray, the Netherlands.
Yvonne C M RensenVincent van Gogh Institute for Psychiatry, Centre of Excellence for Korsakoff and Alcohol-related Cognitive Disorders, Venray, the Netherlands.
Gwenny T L JanssenVincent van Gogh Institute for Psychiatry, Centre of Excellence for Korsakoff and Alcohol-related Cognitive Disorders, Venray, the Netherlands.
Roy P C KesselsVincent van Gogh Institute for Psychiatry, Centre of Excellence for Korsakoff and Alcohol-related Cognitive Disorders, Venray, the Netherlands.ORCID https://orcid.org/0000-0001-9500-9793

Funding

Korsakov Kenniscentrum KKC-U-002-03-ECK
6 · The paper itself

Abstract

BACKGROUND AND

aimsKorsakoff's syndrome is an alcohol-related neurocognitive disorder characterized by episodic memory impairments, apathy, confabulations and poor illness-insight. This meta-analysis aimed to estimate mean effect sizes of performance in social cognition in people with Korsakoff's syndrome (KS) compared with controls.

methodA systematic literature search was conducted in May 2024 to identify research articles that examined social cognition in patients with KS and control groups. Weighted effect sizes (Hedges' g) were calculated for the three levels of social cognition: emotion perception, social interpretation and socio-cognitive integration. There was no restriction on setting. Instruments examining emotion perception (facial emotion recognition and prosody), interpretation (mentalizing, self-awareness and empathy) and socio-cognitive integration (moral reasoning and social knowledge) were used in the included studies.

resultsThirteen studies (n = 622; 292 KS, 330 controls) showed that individuals with KS performed statistically significantly worse across all domains of social cognition compared with controls. Large effect sizes were found in emotion perception [g = -1.14, 95% confidence interval (CI) = -1.46 to -0.81), P < 0.001, I

conclusionsThis meta-analysis shows that people with Korsakoff's syndrome perform statistically significantly worse than controls on socio-cognitive measures, with the largest effect sizes in the perception and interpretation of social information.

Indexed as

Korsakoff SyndromeSocial CognitionSocial PerceptionEmotionsEmpathyHumansalcohol‐related cognitive disordersalcohol use disorderKorsakoff's syndromemeta‐analysisneurocognitive disorderssocial cognition

Identifiers

PMID41255064
PMCPMC12980293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.