ArticleAnnals of medicine2025
Impact of opioid-free anesthesia on the overall benefit of analgesia score after laparoscopic cholecystectomy: protocol and statistical analysis plan for a multicenter, randomized, controlled trial.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Response to letter regarding [Impact of opioid-free anesthesia on the overall benefit of analgesia score after laparoscopic cholecystectomy].Annals of medicine · 2026Article
- Regarding: 'impact of opioid-free anaesthesia on the overall benefit of analgesia score after laparoscopic cholecystectomy: protocol and statistical analysis plan for a multicentre, randomized, controlled trial'.Annals of medicine · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLaparoscopic cholecystectomy is frequently complicated by significant postoperative pain and opioid-related adverse events. Whether opioid-free anesthesia (OFA) improves the overall benefit of analgesia in this setting remains unknown. We aim to compare the effects of OFA versus conventional opioid-based anesthesia on the Overall Benefit of Analgesia Score (OBAS) after laparoscopic cholecystectomy. PATIENTS AND
methodsThis multicenter, randomized, controlled trial will enroll 318 adult patients scheduled for elective laparoscopic cholecystectomy at three teaching hospitals in China. Patients will be allocated 1:1 to receive OFA (dexmedetomidine and esketamine) or opioid-based anesthesia (sufentanil). All patients will receive standardized sevoflurane anesthesia and postoperative multimodal analgesia. The primary endpoint is the OBAS at 24 h after surgery. Secondary endpoints include pain scores on movement at 24 h postoperatively and the incidence of chronic pain at 90 days postoperatively. Exploratory endpoints include intraoperative hemodynamics, rescue analgesia, psychiatric adverse events, length of stay in the post-anesthesia care unit, and length of hospital stay. DISCUSSION: Results of this trial will provide high-level evidence on whether the OFA regimen can improve patients' overall analgesic benefit after laparoscopic cholecystectomy.
trial registrationChinese Clinical Trial Registry (ChiCTR2500099527).
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