ArticleAnnals of medicine2025
Paraventricular nucleus neurons: important regulators of respiratory movement in mice with chronic intermittent hypoxia.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Obstructive sleep apnea as a modifier of endocrine toxicities associated with immune checkpoint inhibitors in lung cancer.Frontiers in immunology · 2026Review
- Substance P-expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus-airway neural pathway.Frontiers in neuroscience · 2026Article
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Authors and funding
5 authors.
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Abstract
objectiveObstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent respiratory disorder. Chronic intermittent hypoxia (CIH) is a key pathophysiological change linked to the development of OSAHS. The paraventricular hypothalamic nucleus (PVN) plays a role in respiratory control. This study aimed to explore a novel treatment for OSAHS through PVN stimulation.
methodThe Cre/LoxP gene expression strategy, along with the viral tracer technique and immunofluorescence staining, was employed to confirm the anatomical relationship between the PVN and the preBötzinger complex (preBötC) in mice. A CIH mouse model was established, and chemogenetics was integrated with whole-body plethysmography (WBP) to monitor the respiratory function changes in CIH mice.
result(1) A notably higher density of c-Fos-positive neurons was detected in the PVN of CIH mice compared to normoxic mice (
conclusionA direct relationship exists between the PVN and preBötC. CIH increased c-Fos expression in respiratory-related nuclei, including the PVN. Modulating the PVN activity impacts MV by adjusting the RF; without influencing arterial blood gas levels. The PVN is probably involved in respiratory control
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