Evidence map›Paper›PMID 41254937›Full record

ArticleRedox report : communications in free radical research2025

Sesamin alleviates drug-induced hepatotoxicity via autophagy enhancement and ferroptosis inhibition.

Jingyi Ren, Ziyi Wang, Yadong Zhang, Huanting Pei, Rui Wen, Zhenao Zhang, Siqi Zhu, Xiaoya Sun, Bowen Yin, Shenghe Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Crosstalk between autophagy and ferroptosis in liver diseases (Review).International journal of molecular medicine · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jingyi RenDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Ziyi WangDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Yadong ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Huanting PeiDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Rui WenDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Zhenao ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Siqi ZhuDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Xiaoya SunDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Bowen YinDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Shenghe LiUndergraduate of College of Public Health, Hebei Medical University, Shijiazhuang, People's Republic of China.
Yuxia MaDepartment of Nutrition and Food Hygiene, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, People's Republic of China.ORCID 0000-0002-3926-2644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. Sesamin (Ses), a natural polyphenolic compound, possesses diverse pharmacological properties. This study was to explore the effects of Ses on APAP-induced liver injury and the underlying molecular mechanism.

methods

resultsSes dramatically alleviated APAP-induced hepatocellular injury

conclusionsOur findings demonstrate that Ses attenuates APAP-induced hepatotoxicity through Foxo1, which mediates both the activation of autophagy and the inhibition of ferroptosis. It provides a new strategy for the prevention and treatment of drug-induced liver injury.

Indexed as

AutophagyChemical and Drug Induced Liver InjuryDioxolesFerroptosisLignansAcetaminophenAnimalsForkhead Box Protein O1HepatocytesHep G2 CellsHumansLiverMaleMiceMice, Inbred C57BLSignal TransductionAcetaminophenDioxolesForkhead Box Protein O1Lignanssesaminacetaminophenautophagydrug-induced hepatotoxicityferroptosisFoxo1liver injuryproteomic analysisSesamin

Identifiers

PMID41254937
PMCPMC12632232

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.