ArticleCardiovascular diabetology2025
Impact of left ventricular dilatation on biventricular function and deformation in diabetes mellitus with reduced ejection fraction: a CMR feature tracking study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundLeft ventricular (LV) dilatation has been found to be associated with poor prognosis in patients with reduced left ventricular ejection fraction (LVEF). However, the relationship between LV dilatation and biventricular myocardial dysfunction in patients with diabetes mellitus (DM) and reduced LVEF unclear.
methodsFrom September 2017 to March 2025, 265 clinically diagnosed patients with DM who underwent cardiac magnetic resonance (CMR) scanning in our hospital were included. According to LVEF and LV dilatation status, these patients were divided into three groups: 122 DM with preserved LVEF (DMpEF) group, 51 DM with reduced LVEF and no LV dilatation (DMrEF-NLVD) group, and 92 DM with dilated cardiomyopathy (DMrEF-DCM) group. Biventricular strain parameters, including left/right ventricular global radial strain (LV-/RVGRS), left/right ventricular global circumferential strain (LV-/RVGCS), and left/right ventricular global longitudinal strain (LV-/RVGLS) were evaluated and compared among the three groups. Additionally, multiple linear regression analysis was performed to assess the independent effect of LV dilatation on biventricular strains in DM patients with reduced LVEF.
resultsSignificant differences were observed in both left and right ventricular strain parameters among the three groups. For left ventricular function, LV global strains progressively declined from the DMpEF group to the DMrEF-NLVD group and further to the DMrEF-DCM group (all p < 0.001). For right ventricular function, RV global strains were significantly more impaired in the DMrEF-DCM group and the DMrEF-NLVD group compared with the DMpEF group (all p < 0.05). The DMrEF-DCM group had decreased RVGCS (- 6.18 ± 3.52 vs. - 8.89 ± 4.15, p < 0.001) compared with the DMrEF-NLVD group. In DM patients with reduced LVEF, multivariable linear regression analysis revealed that LV dilatation was independently associated with reduced LVGCS (β = 0.176, p = 0.009).
conclusionsIn DM patients with reduced LVEF, LV dilatation was associated with biventricular dysfunction and deformation injury. LV dilatation was found to be independently associated with impaired LVGCS, the further decrease of LVGCS in DM patients with reduced LVEF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.