ArticleJournal of translational medicine2025
Unraveling the impact of hsa-miR-518c-5p on placental health: mechanistic insights into preeclampsia pathogenesis.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular pathways and immune microenvironment regulation in stem cell therapy for thin endometrium: a comprehensive narrative review.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundPreeclampsia (PE), a severe hypertensive disorder during pregnancy, is characterized by dysfunctional placental trophoblasts. This study identifies hsa-miR-518c-5p as a key regulator of trophoblast differentiation and invasion, potentially implicated in PE pathology.
methodsIn human PE placentae, the expression of hsa-miR-518c-5p was measured, revealing a significant decrease in the trophoblastic layer. Human trophoblast organoids, villous explants derived from human early villi, and HTR8/SVneo cell line were used to explore the roles of hsa-miR-518c-5p in trophoblast differentiation, migration, and invasion. RNA sequencing was conducted to analyze hsa-miR-518c-5p-mediated transcriptomic changes. Mechanistic studies were performed using western blotting, ubiquitin ligases inhibitor, and co-immunoprecipitation assays. Changes in signaling pathway were validated in human PE placentas.
resultsThe experiments showed that hsa-miR-518c-5p promotes the differentiation of human trophoblast organoids into extravillous trophoblasts (EVTs) and stimulates EVTs migration and invasion. Mechanistically, hsa-miR-518c-5p targets the mRNA of p120 catenin. The p120 catenin protein interacts with WISP2, protecting it from ubiquitin-mediated degradation and modulating the EMT pathway. Elevated levels of p120 catenin and WISP2 were observed in the placentae of PE patients, confirming the regulatory role of hsa-miR-518c-5p.
conclusionsThese findings underscore the importance of hsa-miR-518c-5p in determining EVTs differentiation and infiltration, suggesting its involvement in PE pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.