Evidence map›Paper›PMID 41254663›Full record

ArticleVirology journal2025

The relationship between human papillomavirus genotype distribution and age and the association with high-grade squamous intraepithelial lesions of the cervix or cervical cancer in Jilin Province, China.

Lixia Zhu, Peiyao Li, Yingyao Wang, Shuqi Zhang, Haifeng Xu, Juping Zhang, Juan Chen, Jing Ren, Yitong Wu, Yanjin Yao and 4 more

Abstract read
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lixia Zhu *Department of Obstetrics and Gynecology, Yangzhou University and Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Peiyao Li *Department of Obstetrics and Gynecology, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Suzhou, 215002, China.
Yingyao Wang *Department of Obstetrics and Gynecology, Kunshan Maternal and Child Health Hospital, Kunshan, 215300, China.
Shuqi ZhangDepartment of Obstetrics and Gynecology, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Suzhou, 215002, China.
Haifeng XuDepartment of Obstetrics and Gynecology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Juping ZhangDepartment of Obstetrics and Gynecology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Juan ChenDepartment of Obstetrics and Gynecology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Jing RenDepartment of Obstetrics and Gynecology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Yitong WuDepartment of Obstetrics and Gynecology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Yanjin YaoDepartment of Obstetrics and Gynecology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Yafang HuaDepartment of Nursing, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
Ping LiDepartment of Radiotherapy and Oncology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China. xiaopingfriend@163.com.
Qin LiuDepartment of Obstetrics and Gynecology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China. liuqinchina@163.com.
Lu DanDepartment of Obstetrics and Gynecology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China. Ludan1968@126.com.

Funding

Suzhou Municipal Health Commission Science and Technology Project. LCZX202228The Kunshan Key Research and Development Programme KSF202101The scientific research project of the Jiangsu Provincial Health and Wellness Commission Z2021084
6 · The paper itself

Abstract

Using a retrospective cohort of 21,282 individuals aged 10-89 years (634 males, 20,648 females) from Jilin Province between October 2017 and September 2019, we performed HPV genotyping and colposcopy-directed biopsy to delineate age- and genotype-specific infection patterns. High-risk HPV prevalence peaked in adolescence (≤ 18 years) and declined thereafter, whereas low-risk types showed modest age trends (P < 0.001); women had higher rates than men at every age (P < 0.001). HPV16, 18, 33 and 58 were strongly linked to high-grade squamous intraepithelial lesions or cervical cancer, with adjusted ORs (Model II) of 2.41, 0.53, 2.32 and 1.72, respectively. A U-shaped, nonlinear age relationship emerged, with infection risk threshold ages (fold K) at 26, 42, 30 and 37 years. These findings indicate that HPV vaccination and screening should prioritize women ≤ 26 years and re-engage those > 37 years.

Indexed as

GenotypePapillomaviridaePapillomavirus InfectionsSquamous Intraepithelial LesionsSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsAdolescentAdultAgedAged, 80 and overAge FactorsChildChinaFemaleHuman Papillomavirus VirusesHumansHuman papillomavirus genotype Distribution, Cervical intraepithelial Neoplasia, Uterine cervical Neoplasms, Non-linear, threshold ages

Identifiers

PMID41254663
PMCPMC12625315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.