ArticleBMC oral health2025
Palate invasion in cT3/4 maxillary sinus squamous cell carcinoma: a study of at least 5-year follow-up.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe prognostic significance of palate invasion in cT3/4N0 maxillary sinus squamous cell carcinoma (MS-SCC) remains ambiguous. This study endeavors to elucidate the impact of palate invasion on the prognosis of cT3/4N0 MS-SCC and to ascertain whether diverse neck management strategies modulate this effect.
methodsA retrospective analysis was undertaken on a cohort of patients with surgically managed cT3/4N0 MS-SCC, all of whom had a minimum follow-up period of 5 years. The influence of palate invasion on locoregional control (LRC) and overall survival (OS) was scrutinized using the Cox proportional hazards model. Additionally, the relationship between palate invasion and occult metastasis was evaluated through logistic regression analysis.
resultsThe study encompassed 133 patients, among whom 39 (29.3%) exhibited palate invasion. Elective neck dissection was performed in 58 patients, while the remaining subjects received elective neck irradiation. The Cox model for LRC revealed that patients with palate invasion faced a significantly elevated risk of locoregional recurrence (HR: 1.47; 95%CI: 1.17–1.90) compared to those without palate invasion. Similarly, the hazard ratio for palate invasion in the OS model was 1.64 (95%CI: 1.20–1.98), indicating a significantly poorer prognosis in cases with palate invasion. Both elective neck dissection and elective neck irradiation demonstrated comparable LRC and OS outcomes in patients with and without palate invasion. Occult metastasis was detected in 12 patients, and those with palate invasion exhibited nearly a one-fold increase in the risk of lymph node (LN) metastasis (OR: 1.68; 95%CI: 1.24–3.11) relative to those without palate invasion.
conclusionPalate invasion exerts a significantly adverse effect on both occult metastasis and overall prognosis. However, its influence on prognosis appears to be mitigated when elective neck dissection or elective neck irradiation is employed, suggesting a limited impact under these management strategies.
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