ArticleBMC infectious diseases2025
Clinical characteristics and risk factors associated with 28-day mortality among maintenance hemodialysis patients infected with Omicron variant of SARS-CoV-2.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe SARS-CoV-2 variant of concern (VOC), Omicron, is characterized by lower virulence and pathogenicity, yet it exhibits high infectivity. Data on Omicron COVID-19 in maintenance hemodialysis (MHD) are scarce. In the present study, we aimed to investigate the clinical characteristics, outcomes and risk factors associated with 28-day mortality among these patients with COVID-19 infections.
methodsWe conducted a retrospective analysis of data from 211 MHD patients infected with the SARS-CoV-2 Omicron variant. These patients, from ten dialysis centers across Shanghai, were consecutively admitted to our designated hospital from March 28, 2022, to June 18, 2022. We compared demographics and clinical characteristics within 48 h of hospitalization between patients who survived and those who did not.
resultsThe 28-day mortality rate was 9.5%. A Cox multivariate regression analysis identified several predictors of 28-day mortality: pre-existing cardiovascular disease (hazard ratio [HR] 8.09, 95% confidence interval [CI] 2.66-24.62, P < 0.001), elevated C reactive protein level (HR 1.00, 95% CI 1.00-1.01, P = 0.015), high interleukin-6 (IL-6) level (≥ 21.6 pg/ml, HR 8.52, 95% CI 1.09-66.42, P = 0.041), and high N-terminal pro-B-type natriuretic peptide (NT-proBNP) level (≥ 35000 pg/ml, HR 3.56, 95% CI 1.11-11.44, P = 0.033). Combining these four parameters may serve as a valuable tool for identifying MHD patients at high risk of 28-day mortality.
conclusionPre-existing cardiovascular diseases and inflammatory storm were risk factors for critical COVID-19 or death in MHD patients. Special attention and an appropriate level of care are necessary for these high-risk hemodialysis patients. CLINICAL TRIAL: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.