ReviewActa neurologica Belgica2025
Navigating anterior pituitary dysfunction after traumatic brain injury: mechanisms, diagnosis, and management.
Review in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
Post-traumatic hypopituitarism (PTHP), a condition primarily affecting the anterior pituitary, represents a significant and frequently underdiagnosed consequence of traumatic brain injury (TBI). Its clinical course is dynamic, with deficiencies that can be transient, persistent, or of late onset, profoundly impacting both acute prognosis and long-term cognitive and functional recovery. This review summarizes the complex pathophysiology of PTHP, covering established mechanisms such as mechanical and vascular insults, while also discussing emerging concepts including NLRP3 inflammasome-driven pyroptosis, cellular senescence, and the potential role of pituitary-resident folliculostatellate (FS) cells in the secondary injury cascade. From a clinical perspective, the review emphasizes a longitudinal approach to diagnosis and management that spans the acute to chronic phases, addressing key diagnostic pitfalls and summarizing evidence-based therapeutic strategies. By synthesizing current pathophysiological concepts and clinical practices, this review aims to enhance clinical awareness, bridge the knowledge-translation gap, and provide a resource to help optimize care for this vulnerable patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.