ArticleAnalytical and bioanalytical chemistry2025
Signal enhancement of lipids and glycans using ammonium fluoride for IR-MALDESI mass spectrometry imaging.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Spatially resolved lipids in a mouse brain model of globoid cell leukodystrophy via IR-MALDESI MSI and parallel reaction monitoring MSI.Analytical and bioanalytical chemistry · 2026Article
- Exploring ammonium salt doping to enhance ion abundance for quantitative mass spectrometry imaging.Analytical and bioanalytical chemistry · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Mass spectrometry imaging (MSI) is an analytical technique that enables the simultaneous detection and localization of hundreds to thousands of molecules across a tissue surface. The addition of ammonium fluoride to the electrospray or to tissue samples has been shown to increase the signal of lipids in both nano-DESI-MSI and MALDI-MSI, respectively. Herein, this strategy is applied to infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) which demonstrated signal enhancement for both lipids and N-linked glycans using 70 µM and 350 µM NH
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Registered trials
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