ArticleMolecular neurobiology2025
Neutralizing XCL1 Attenuates Brain Injury and Reduces Lymphocyte and Dendritic Cell Recruitment Following Intracerebral Hemorrhage in Mice.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The interaction between chemokine-C-motif ligand 1 (XCL1) and X-C motif chemokine receptor 1 (XCR1), members of the CXC chemokine family, amplifies immune-inflammatory responses via lymphocyte activation. The influence of lymphocyte infiltration on stroke outcome underscores the importance of investigating the potential role of the XCL1-XCR1 axis in stroke pathophysiology. In this investigation, we examined the expression of XCL1 and XCR1 in the hemorrhagic brain in mice subjected to Ⅶ-S collagenase-induced intracerebral hemorrhage (ICH) in the left striatum. We also evaluated the efficacy of the XCL1-XCR1 axis on neuroinflammation and ICH outcomes by neutralizing XCL1. The results unveiled that infiltrating immunocytes and microglia manifest XCL1 immunoreactivity and that XCR1-positive cells co-express distinct markers of glia and neurons within the hemorrhagic brain. Notably, a decrease in the infiltration of helper T cells, cytotoxic T cells, natural killer cells, dendritic cells (DCs), and XCR1
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