Evidence map›Paper›PMID 41254331›Full record

ArticleObesity surgery2025

Gut Microbiota Composition and Arterial Hypertension Improvement Post-Roux-en-Y Gastric Bypass: GATEWAY Trial Sub-Analysis After 5 Years.

Ângela C Bersch-Ferreira, Danielle Cristina Fonseca, Lucas Tramujas, Carlos A Schiavon, Renato H Nakagawa Santos, Rachel H V Machado, Alexandre Biasi Cavalcanti, Aline Marcadenti

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Article in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Foods (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ângela C Bersch-FerreiraHcor Research Institute, Hospital do Coração, São Paulo, Brazil.
Danielle Cristina FonsecaPROADI-SUS Office, Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
Lucas TramujasHcor Research Institute, Hospital do Coração, São Paulo, Brazil.
Carlos A SchiavonHcor Research Institute, Hospital do Coração, São Paulo, Brazil.
Renato H Nakagawa SantosHcor Research Institute, Hospital do Coração, São Paulo, Brazil.
Rachel H V MachadoHcor Research Institute, Hospital do Coração, São Paulo, Brazil.
Alexandre Biasi CavalcantiHcor Research Institute, Hospital do Coração, São Paulo, Brazil.
Aline MarcadentiHcor Research Institute, Hospital do Coração, São Paulo, Brazil. marcadenti.aline@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to explore the relationship between gut microbiota composition and hypertension remission in individuals with obesity and hypertension who underwent Roux-en-Y gastric bypass (RYGB) surgery five years prior.

methodsThis is a sub-analysis of the GATEWAY trial using cross-sectional data from participants five years post-surgery. Three groups were included: patients who underwent RYGB and achieved hypertension remission (Group 1, n = 12), patients who underwent RYGB but did not achieve remission (Group 2, n = 12), and a control group of individuals with obesity and hypertension who did not undergo surgery (Group 3, n = 15). Gut microbiota composition was evaluated using metagenomic sequencing of fecal samples, with taxonomic classification at the phylum, class, and order levels.

resultsNo statistically significant differences were found in overall microbiota composition between the groups. However, microbial richness was higher in both surgical groups compared to the control group, suggesting a potential link between bariatric surgery and increased gut microbial diversity.

conclusionWhile gut microbiota composition did not significantly differ between individuals with and without hypertension remission, the observed increase in microbial richness among those undergoing bariatric surgery underscores the complex interplay between obesity treatment, gut microbiota, and blood pressure regulation. Further research is needed to elucidate these long-term relationships.

Indexed as

Gastric BypassGastrointestinal MicrobiomeHypertensionObesity, MorbidAdultCross-Sectional StudiesFecesFemaleHumansMaleMiddle AgedRemission InductionTreatment OutcomeBariatric surgeryGut microbiotaHypertensionLong-term follow-upRoux-en-Y gastric bypass

Identifiers

PMID41254331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.