Evidence map›Paper›PMID 41254329›Full record

ArticleCommunications medicine2025

Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events.

Mick J M van Eijs, M Marlot van der Wal, Hedi-Britt Klotškova, Noël M M Dautzenberg, Mark Schuiveling, Rik J Verheijden, Fiona D M van Schaik, Bas Oldenburg, Stefan Nierkens, UNICIT Consortium and 2 more

Erratum issuedAbstract read
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In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mick J M van EijsDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-9763-6704
M Marlot van der WalCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0003-4554-9059
Hedi-Britt KlotškovaCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0009-0000-3291-5000
Noël M M DautzenbergCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Mark SchuivelingDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-2631-7271
Rik J VerheijdenDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0003-1966-1063
Fiona D M van SchaikDepartment of Gastroenterology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Bas OldenburgDepartment of Gastroenterology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Stefan NierkensCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
UNICIT Consortium
Karijn P M Suijkerbuijk *Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0003-3604-5430
Femke van Wijk *Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. f.vanwijk@umcutrecht.nl.ORCID http://orcid.org/0000-0001-8343-1356

Funding

Bristol-Myers Squibb (Bristol-Myers Squibb Company) CA209-6JY
6 · The paper itself

Abstract

backgroundHigh-dose steroids constitute the cornerstone of first-line treatment for immune-related adverse events (irAEs) associated with immune checkpoint inhibitors, but compromise antitumor immunity. A deeper understanding of irAEs and their response to steroids can improve management.

methodsUsing a multi-omics approach, we investigated blood- and tissue-based correlates of steroid response, focusing on gastro-intestinal irAEs, in the largest cohort to date.

resultsHere we show clear trends for elevated T

conclusionsThese findings highlight rapid steroid effects on circulating cells and irAE-affected tissue and support that an enhanced type 1/type 17 response may be associated with steroid non-response in irAEs. Validation of these findings in larger cohorts is warranted.

Identifiers

PMID41254329
PMCPMC12627558

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.