Evidence map›Paper›PMID 41254323›Full record

ArticleMolecular psychiatry2026

Quantitative monitoring of ketamine's impact on synaptic density using

Cassandre Corvo, Sébastien Goutal, Indira Mendez-David, Sarah Leterrier, Fabien Caille, Wadad Saba, Romain Colle, Emmanuelle Corruble, Vincent Lebon, Michel Bottlaender and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cassandre CorvoUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Sébastien GoutalUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Indira Mendez-DavidUniversité Paris-Saclay, UVSQ, Centre de recherche en Epidémiologie et Santé des Populations (CESP), UMR 1018, CESP-Inserm, Team MOODS, Faculté de Pharmacie, Bâtiment Henri Moissan, Orsay, France.
Sarah LeterrierUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Fabien CailleUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Wadad SabaUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Romain ColleUniversité Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations (CESP), UMR1018, CESP-Inserm, Team MOODS, Faculté de Médecine, Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0002-2549-4495
Emmanuelle CorrubleUniversité Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations (CESP), UMR1018, CESP-Inserm, Team MOODS, Faculté de Médecine, Le Kremlin-Bicêtre, France.
Vincent LebonUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Michel BottlaenderUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Claire LeroyUniversité Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France.
Denis J David *Université Paris-Saclay, UVSQ, Centre de recherche en Epidémiologie et Santé des Populations (CESP), UMR 1018, CESP-Inserm, Team MOODS, Faculté de Pharmacie, Bâtiment Henri Moissan, Orsay, France.ORCID http://orcid.org/0000-0002-0506-6688
Nicolas Tournier *Université Paris-Saclay, Inserm, CNRS, CEA, Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Service Hospitalier Frédéric Joliot, Orsay, France. nicolas.tournier@cea.fr.ORCID http://orcid.org/0000-0002-0755-2030

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-11-INBS-0006Agence Nationale de la Recherche (French National Research Agency) ANR-22-CE17-0015
6 · The paper itself

Abstract

Ketamine was shown to promote synaptogenesis, which is thought to account for its antidepressant effects through the restoration of lost synaptic connections observed in depression. PET imaging using

Indexed as

AnxietyDepressionKetamineAnimalsAntidepressive AgentsBrainCarbon RadioisotopesCorticosteroneDisease Models, AnimalMaleMiceMice, Inbred C57BLPositron-Emission TomographyPyridinesPyrrolidinonesSynapses1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneAntidepressive AgentsCarbon RadioisotopesCorticosteroneKetaminePyridinesPyrrolidinones

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.