Evidence map›Paper›PMID 41254301›Full record

ArticleNPJ digital medicine2025

Artificial intelligence prediction of age from echocardiography as a marker for cardiovascular disease.

Meenal Rawlani, Hirotaka Ieki, Christina Binder, Victoria Yuan, I-Min Chiu, Ankeet Bhatt, Joseph E Ebinger, Yuki Sahashi, Andrew P Ambrosy, Hiroki Usuku and 5 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Meenal RawlaniDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Hirotaka IekiDivision of Cardiology, Department of Medicine, Stanford University, Palo Alto, CA, USA.
Christina BinderDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Victoria YuanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
I-Min ChiuDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ankeet BhattDepartment of Cardiology and Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Joseph E EbingerDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Yuki SahashiDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Andrew P AmbrosyDepartment of Cardiology and Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Hiroki UsukuDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan.
Kenichi TsujitaDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan.
Paul ChengDivision of Cardiology, Department of Medicine, Stanford University, Palo Alto, CA, USA.
Alan C KwanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Susan ChengDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
David OuyangDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. David.ouyang@kp.org.

Funding

Deep Learning Based Phenotyping and Outcomes Prediction for Valvular Heart DiseaseR01HL173526 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI David Ouyang · 2024 to 2026
$2.5M
Artificial Intelligence Imaging Biomarkers of Longitudinal Cardiovascular StressR01HL173487 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI David Ouyang · 2025 to 2026
$1.4M
Deep Learning Assessment of the Right Ventricle: Function, Etiology, and PrognosisR00HL157421 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI OUYANG, DAVID · 2023 to 2025
$747k
Japan Society for the Promotion of Science 24K10526NHLBI NIH HHS R00 HL157421NHLBI NIH HHS R01 HL173487NHLBI NIH HHS R01 HL173526
6 · The paper itself

Abstract

While chronological age is a universal risk predictor across most populations and diseases, distinguishing between biologically older from younger individuals may identify individuals with accelerated or delayed cardiovascular aging. This study presents a deep learning model to predict age from echocardiogram videos, leveraging 2,610,266 videos from 166,508 studies from 90,738 patients. Leveraging multi-view echocardiography, our model achieved a mean absolute error (MAE) of 6.76 (6.65-6.87) years and a coefficient of determination (R

Identifiers

PMID41254301
PMCPMC12627499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.