ArticleCommunications biology2025
A critical role of copper homeostasis in the virulence of Klebsiella pneumoniae.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- Conserved vulnerability of SoxR underlies zinc-mediated redox disruption and synergistic killing inmBio · 2026Article
- CueO Possesses Copper Detoxification Activity Linking Bacterial Virulence and Drug Resistance in Brucella.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- CuiT is a Cu importer required for metal homeostasis inBiochemistry and biophysics reports · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
Pathogens are exposed to toxic levels of copper during infection, and copper tolerance may represent a general virulence mechanism utilized by bacteria to evade host defenses. Therefore, the precise regulation of copper homeostasis in bacteria is crucial for coping with external copper stress. However, little is known about the role of copper homeostasis in the virulence of Klebsiella pneumoniae (K. pneumoniae), an important clinical pathogen. This study focused on the potential systems of copper homeostasis in K. pneumoniae and found that deletion of Cue system genes significantly reduced bacterial copper tolerance. The decreased tolerance was due to increased intracellular copper accumulation and greater susceptibility to oxidative stress in the mutants. Furthermore, ΔcopA, ΔcueO ΔcopA, and ΔcueO ΔcusRS mutants may also be associated with reduced virulence and increased susceptibility to phagocytosis or killing by macrophages. Notably, the decreased virulence of ΔcopA and ΔcueO ΔcopA mutants may be associated with impaired capsule polysaccharide and biofilm formation. The ΔcueO ΔcusRS mutant also appeared to display increased sensitivity to hydrogen peroxide. Importantly, these attenuated mutants demonstrated protective effects and may serve as potential vaccine candidates. Altogether, this study identifies the critical role of copper homeostasis in bacterial copper tolerance and the virulence of K. pneumoniae.
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Registered trials
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