Evidence map›Paper›PMID 41254276›Full record

ArticleMikrochimica acta2025

Ultra-stable fluorinated poly-A spherical nucleic acid for high-fidelity intracellular MiRNA-21 imaging.

Jiaying Chen, Sang Lin, Tao Zeng, Xiuping Cao, Shiqing Li, Xiuyun Lin, Chao Xing, Chunhua Lu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiaying Chen *MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P.R. China.
Sang Lin *MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P.R. China.
Tao Zeng *MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P.R. China.
Xiuping CaoMOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P.R. China.
Shiqing LiMOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P.R. China.
Xiuyun LinDepartment of Hepatopancreatobiliary Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, P. R. China.
Chao XingCollege of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, P.R. China. chaoxing@mju.edu.cn.
Chunhua LuMOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P.R. China. chunhualu@fzu.edu.cn.

Funding

National Natural Science Foundation of China 22174019
6 · The paper itself

Abstract

Polyadenine (poly-A) based spherical nucleic acids (SNAs) have received substantial attention owing to their precise regulation of DNA density and orientation by adjusting the length of adenine bases, which enhances the efficiency of DNA hybridization and sensitivity of target detection. Their application, however, is limited by poor stability under high salt conditions or prolonged storage, and insufficient resistance to biological thiols. In this study, a 2'-fluorinated poly-A (FpA) functionalized SNAs (Au/FpA) has been constructed to address these issues. The resulting Au/FpA can complete the entire preparation process within 1.5 h and exhibit stability under high temperatures (up to 90 °C), high salt concentrations (up to 0.8 M NaCl), and a broad pH range (3-12). Furthermore, an Au/FpA probe was constructed for the accurate and high-efficiency imaging of microRNA (miRNA) in living cells. The Au/FpA probe maintained the high-fidelity performance characteristics of Au/FpA SNAs, effectively resisting biological thiol interference and accurately identifying target cancer cells in mixed culture systems. These fluorinated poly-A-based SNAs offer an efficient method for the rapid preparation of high-performance SNAs and open new avenues for innovative designs in biosensing and clinical diagnostic applications.

Indexed as

MicroRNAsPoly AFluorescent DyesGoldHalogenationHumansNucleic Acid HybridizationFluorescent DyesGoldMicroRNAsMIRN21 microRNA, humanPoly ApolyadenineMicro-RNA imaging; Fluorescence detectionPolyadenineSpherical nucleic acids

Identifiers

PMID41254276

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