Evidence map›Paper›PMID 41254222›Full record

ArticleNature immunology2025

Analysis of the three-dimensional genome of exhausted CD8

Ruifeng Li, Kun Wei, Qinli Sun, Bowen Xie, Peng Wei, Tian Xie, Xinyi Guo, Yongzhen Chen, Birui Pan, Zixuan Zhao and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. ApolipoproteinEiScience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Exhausted CD8Nature immunology · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Immune decoding from a multi-omics perspective: Redefining pancreatic cancer tumor microenvironment.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Tumor-driven stabilization of CD8Frontiers in immunology · 2026
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruifeng Li *Institute for Immunology, Tsinghua University, Beijing, China.
Kun Wei *Institute for Immunology, Tsinghua University, Beijing, China.
Qinli SunInstitute for Immunology, Tsinghua University, Beijing, China.
Bowen XieInstitute for Immunology, Tsinghua University, Beijing, China.
Peng WeiInstitute for Immunology, Tsinghua University, Beijing, China.
Tian XieInstitute for Immunology, Tsinghua University, Beijing, China.
Xinyi GuoInstitute for Immunology, Tsinghua University, Beijing, China.
Yongzhen ChenInstitute for Immunology, Tsinghua University, Beijing, China.
Birui PanInstitute for Immunology, Tsinghua University, Beijing, China.
Zixuan ZhaoInstitute for Immunology, Tsinghua University, Beijing, China.
Ling NiInstitute for Immunology, Tsinghua University, Beijing, China.
Chen DongWestlake University School of Medicine, Hangzhou, China. dongchen@westlake.edu.cn.ORCID http://orcid.org/0000-0002-0084-9130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD8

Indexed as

CD8-Positive T-LymphocytesCell DifferentiationInterferon Regulatory FactorsNeoplasmsAnimalsCCCTC-Binding FactorChromatinHumansInterferon Regulatory Factor-8MiceMice, Inbred C57BLMice, KnockoutPromoter Regions, GeneticCCCTC-Binding FactorChromatinCtcf protein, mouseInterferon Regulatory Factor-8Interferon Regulatory Factors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.