Evidence map›Paper›PMID 41254203›Full record

ArticleCommunications biology2025

Lignocellulose degradation capabilities and distribution of antibiotic resistance genes and virulence factors in Clostridium from the gut of giant pandas.

Wenwen Deng, Caiwu Li, Yan Huang, Chengxi Liu, Rengui Li, Ti Li, Daifu Wu, Yongguo He, Desheng Li, Shengzhi Yang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenwen Deng *College of Resources, Sichuan Agricultural University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0001-6816-1546
Caiwu Li *Key Laboratory of State Forestry and Grassland Administration (SFGA) on Conservation Biology of Rare Animals in the Giant Panda National Park, The China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, Sichuan, China.
Yan HuangKey Laboratory of State Forestry and Grassland Administration (SFGA) on Conservation Biology of Rare Animals in the Giant Panda National Park, The China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, Sichuan, China.
Chengxi LiuCollege of Resources, Sichuan Agricultural University, Chengdu, Sichuan, China.
Rengui LiKey Laboratory of State Forestry and Grassland Administration (SFGA) on Conservation Biology of Rare Animals in the Giant Panda National Park, The China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, Sichuan, China.
Ti LiKey Laboratory of State Forestry and Grassland Administration (SFGA) on Conservation Biology of Rare Animals in the Giant Panda National Park, The China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, Sichuan, China.
Daifu WuKey Laboratory of State Forestry and Grassland Administration (SFGA) on Conservation Biology of Rare Animals in the Giant Panda National Park, The China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, Sichuan, China.
Yongguo HeKey Laboratory of State Forestry and Grassland Administration (SFGA) on Conservation Biology of Rare Animals in the Giant Panda National Park, The China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, Sichuan, China.
Desheng LiKey Laboratory of State Forestry and Grassland Administration (SFGA) on Conservation Biology of Rare Animals in the Giant Panda National Park, The China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, Sichuan, China.
Shengzhi YangCollege of Life Science, Sichuan Agricultural University, Ya'an, Sichuan, China. sclzysz@qq.com.ORCID http://orcid.org/0000-0002-9029-1707
Likou ZouCollege of Resources, Sichuan Agricultural University, Chengdu, Sichuan, China. zoulikou@sicau.edu.cn.ORCID http://orcid.org/0000-0002-5635-8277
Ke ZhaoCollege of Resources, Sichuan Agricultural University, Chengdu, Sichuan, China. zhaoke82@126.com.ORCID http://orcid.org/0000-0001-8537-6020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clostridium is a vital gut anaerobe in giant pandas (GPs), aiding bamboo digestion and gut homeostasis. The present study optimizes anaerobic culturing to isolate Clostridium species from GPs, evaluating their ecological roles in bamboo digestion while assessing associated pathogenic and antibiotic resistance threats. The results show that the enriching samples in liquid media facilitated the isolation of Clostridium species. A total of 14 species are obtained, with C. perfringens, C. sardiniense, and C. baratii being most prevalent. 86.30% of strains exhibit lignocellulose-degrading activity, with all C. butyricum strains displaying activity for β-glucosidase, xylanase, and manganese peroxidase. Genomic analysis identifies carbohydrate-active enzymes and metabolic pathways involved in lignocellulose degradation, short-chain fatty acid production, and essential amino acid biosynthesis. C. butyricum possesses the most hemicellulose- and cellulose-degrading genes. We also identify 19 antibiotic resistance genes (ARGs), predominantly glycopeptide-resistant van genes, and 23 virulence factors (VFs) encoded by 408 virulence genes (VGs). Notably, C. perfringens harbors the most ARGs and VFs, some of which are flanked by mobile genetic elements, suggesting risks of horizontal gene transfer. Overall, this study describes the dual role of Clostridium in GPs, contributing to dietary adaptation while also posing potential hazards due to pathogenic traits and antimicrobial resistance.

Indexed as

ClostridiumDrug Resistance, BacterialDrug Resistance, MicrobialGastrointestinal MicrobiomeLigninUrsidaeVirulence FactorsAnimalsPhylogenyLigninlignocelluloseVirulence Factors

Identifiers

PMID41254203
PMCPMC12627601

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.