Evidence map›Paper›PMID 41254193›Full record

ArticleBone marrow transplantation2026

Late hematologic toxicity after CAR T-cell therapy in large B-cell lymphoma: incidence, risk factors, and clinical impact.

Magdalena Corona, Samantha Brown, Kai Rejeski, Jessica R Flynn, Sean M Devlin, Sandeep Raj, Alejandro Luna de Abia, Richard J Lin, Michael Scordo, Gunjan L Shah and 10 more

Abstract read
In one paragraph

Article in Bone marrow transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Magdalena CoronaAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6553-0171
Samantha BrownDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5352-974X
Kai RejeskiAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-3905-0251
Jessica R FlynnDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sean M DevlinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6801-720X
Sandeep RajAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alejandro Luna de AbiaAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Richard J LinAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-0834-7880
Michael ScordoAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gunjan L ShahAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9977-0456
M Lia PalombaCellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alexander P BoardmanLymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lorenzo FalchiLymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jennifer LueLymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gilles SallesLymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9541-8666
Jae ParkCellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sergio A GiraltAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1944-5053
Miguel-Angel PeralesAdult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-5910-4571
Roni Shouval *Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9827-8032
Parastoo B Dahi *Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. dahip@mskcc.org.ORCID 0000-0002-0794-3226

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
A multimodal approach for precision immuno-oncology in lymphoma treated with CAR-T cellsK08CA282987 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Roni Shouval · 2023 to 2026
$1.1M
National Institutes of Health/National Cancer Institute (NIH/NCI) P30-CA008748NCI NIH HHS K08 CA282987NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Late Immune Effector Cell-Associated HematoToxicity (ICAHT) is a recognized complication following CAR T therapy, yet their incidence and clinical consequences remain poorly defined. We assessed early and late hematotoxicity in 290 patients with large B-cell lymphoma receiving CAR T therapy. Early ICAHT ( ≤ 30 days post-infusion) occurred in 78% of patients (grade 1: 22%, grade 2: 26%, grade 3: 22%, grade 4: 8.1%). Cumulative incidence of late ICAHT ( > 30 days post-infusion) by day 100 was 45% (95% CI 39-51) for any grade, 40% (95% CI 34-46) for grade≥2, 22% (95% CI 17-27) for grade ≥3, and 7.2% (95% CI 4.4-11) for grade 4. Cumulative incidences of late moderate-severe thrombocytopenia ( < 50 × 10

Indexed as

Immunotherapy, AdoptiveLymphoma, Large B-Cell, DiffuseAdultAgedFemaleHumansIncidenceMaleMiddle AgedRisk FactorsThrombocytopenia

Identifiers

PMID41254193
PMCPMC13392488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.