Evidence map›Paper›PMID 41254163›Full record

ArticleNature genetics2025

Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes.

Pedro Romero Charria, Cristina Navarrete, Vladimir Ovchinnikov, Lan Xu, Luke A Sarre, Victoria Shabardina, Ewa Ksiezopolska, Elena Casacuberta, David Lara-Astiaso, Arnau Sebé-Pedrós and 1 more

Abstract read
In one paragraph

Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic NProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. A PIWI protein-dependent DNA N6-adenine methylation pathway inbioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pedro Romero CharriaSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID http://orcid.org/0009-0007-9833-1199
Cristina NavarreteCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Vladimir OvchinnikovSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Lan XuSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-8978-9233
Luke A SarreSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Victoria ShabardinaInstitut de Biologia Evolutiva (CSIC-UPF), Barcelona, Spain.ORCID http://orcid.org/0000-0002-8898-8660
Ewa KsiezopolskaCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Elena CasacubertaInstitut de Biologia Evolutiva (CSIC-UPF), Barcelona, Spain.
David Lara-AstiasoDepartment of Haematology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8686-4675
Arnau Sebé-PedrósCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0002-9896-9746
Alex de MendozaSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. a.demendozasoler@qmul.ac.uk.ORCID http://orcid.org/0000-0002-6441-6529

Funding

EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) 950230EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 851647Ministerio de Economía, Industria y Competitividad, Gobierno de España (Ministerio de Economía, Industria y Competitividad) PID2021-124757NB-I00Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) PID2020-120609GB-I00
6 · The paper itself

Abstract

DNA methylation is a key regulator of eukaryotic genomes, most commonly through 5-methylcytosine (5mC). In contrast, the existence and function of N

Indexed as

AdenineChromatinDNA MethylationEukaryotaTranscription, GeneticAdenineChromatin

Identifiers

PMID41254163
PMCPMC12695648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.