Evidence map›Paper›PMID 41254057›Full record

ArticleScientific reports2025

Polymethoxyflavones from Kaempferia parviflora stimulate melanogenesis by blocking the TPC2 channel.

Pattara Poungcho, Rachel Tang, Rita Hairani, Carla Abrahamian, Ponsawan Netcharoensirisuk, Warinthorn Chavasiri, Chatchai Chaotham, Christian Grimm, Wanchai De-Eknamkul

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Pattara PoungchoPharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Rachel TangWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig Maximilian University, Munich, 80539, Germany.
Rita HairaniCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Carla AbrahamianDepartment of Cardiology, German Heart Centre, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich, Munich, 80636, Germany.
Ponsawan NetcharoensirisukDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Warinthorn ChavasiriCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Chatchai ChaothamDepartment of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Christian GrimmWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig Maximilian University, Munich, 80539, Germany. christian.grimm@med.uni-muenchen.de.
Wanchai De-EknamkulDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. wanchai.d@chula.ac.th.

Funding

This research project is supported by the Second Century Fund (C2F) Chulalongkorn University and the 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endow-ment Fund) Batch #51 Round 1/2022 Academic Year 2022 Grant no. GCUGR1125651018D
6 · The paper itself

Abstract

Kaempferia parviflora, well-known as Thai ginseng (Krachaidum), has been used as a medicinal plant and food source for centuries. Its rhizome contains several flavonoids, particularly poly-O-methylated flavones (also known as polymethoxyflavones). We previously found that K. parviflora extract had a strong stimulatory effect on melanogenesis in B16F10 mouse melanoma cells. The aim of this study was to investigate the melanogenic stimulation exerted by various O-methylated flavonoids from K. parviflora in human melanoma cells and elucidate the mechanism of action of the most active compound. MNT-1 cells were used to screen for the most potent O-methylated flavonoid, and its effects on some key steps in melanin biosynthesis would subsequently be investigated. The poly-O-methylated flavone 3,5,7,3',4'-pentamethoxyflavone (PMF) exhibited the strongest melanogenesis-stimulating activity among the 13 O-methylated flavones isolated from K. parviflora. It was shown to enhance tyrosinase (TYR) activity by upregulating the levels of TYR and TYR-related protein 1 (TRP-1) via its inhibitory effect on two-pore channel 2 (TPC2). In conclusion, poly-O-methylated flavones, especially PMF, were suggested as a potential group of flavonoids that could stimulate melanin production by inhibiting the activity of the TPC2 channel, leading to increased TYR and TRP-1 activities.

Indexed as

FlavonesMelaninsZingiberaceaeAnimalsCell Line, TumorHumansMelanogenesisMiceMonophenol MonooxygenasePlant ExtractsFlavonesMelaninsMonophenol MonooxygenasePlant Extracts3,5,7,3′,4′-pentamethoxyflavoneKaempferia parvifloraMelanogenesisPoly-O-methylated flavonesTPC2 channelTyrosinase

Identifiers

PMID41254057
PMCPMC12627424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.