Evidence map›Paper›PMID 41254038›Full record

ArticleScientific reports2025

Calcium hydroxide nanoparticles induce apoptotic cell death in human pancreatic cancer cells through over ROS-driven genomic instability and mitochondrial dysfunction.

Hanan R H Mohamed, Hagar Magdy, Yusuf Elberry, Maryam Ismail, Maivel Michael, Nourhan Eltayeb, Gehan Safwat, Ayman Diab

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanan R H MohamedDepartment of Zoology, Faculty of Science, Cairo University, Giza, Egypt. hananeeyra@cu.edu.eg.
Hagar MagdyFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Yusuf ElberryFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Maryam IsmailFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Maivel MichaelFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Nourhan EltayebFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Gehan SafwatFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Ayman DiabFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aggressive nature of pancreatic cancer, coupled with the limitations of current treatment options, underscores the urgent need for more effective and targeted therapies. Nanoparticle-based approaches offer promising alternatives, with calcium hydroxide nanoparticles (Ca(OH)

Indexed as

ApoptosisCalcium HydroxideNanoparticlesPancreatic NeoplasmsCell Line, TumorDrug Screening Assays, AntitumorGene Expression Regulation, NeoplasticGenomic InstabilityHumansInhibitory Concentration 50MitochondriaMitochondrial MembranesReactive Oxygen SpeciesCalcium HydroxideReactive Oxygen SpeciesCa(OH)2 NPsDNA stabilityMitochondrial apoptosisPANC-1 cellsROS generation

Identifiers

PMID41254038
PMCPMC12627578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.